Как-то не густо. Есть один триал, включающий 20 детей, причем основной целью исследования является вовсе не оценка влияния витаминов, а влияние на нутриентный статус ризперидона.
Dietary status and impact of risperidone on nutritional balance in children with autism: a pilot study.
Lindsay RL, Eugene Arnold L, Aman MG, Vitiello B, Posey DJ, McDougle CJ, Scahill L, Pachler M, McCracken JT, Tierney E, Bozzolo D.
Children's Health Center of St. Joseph's Hospital and Medical Center, Arizona 85013, USA.
rlindsay@chw.edu
BACKGROUND: Risperidone may be effective in improving tantrums, aggression, or self-injurious behaviour in children with autism, but often leads to weight gain. METHOD: Using a quantitative Food Frequency Questionnaire (FFQ), we prospectively examined the nutritional intake of 20 children with autism participating in a randomised placebo-controlled trial of risperidone for disruptive behaviours. RESULTS: At baseline, the mean intakes for macronutrients, vitamins and minerals exceeded Dietary Reference Intakes (DRIs). However there was substantial inter-participant variability, with individual deficiencies (<80% of DRI) in the intake of calcium (9 of 20 participants), pantothenic acid (6 of 20), vitamin D (5 of 20) and vitamin K (8 of 20). For the participants for whom FFQs were available, there was an increase in weight and an increase in vitamin K intake after 2 months of risperidone treatment (n = 9) compared to placebo (n = 8). An additional 4 months of risperidone treatment (n = 8) did not result in significant changes in reported nutritional balance. CONCLUSION: These pilot data suggest that treatment with risperidone did not significantly affect the nutritional balance of this small group of children.
PMID: 17178532 [PubMed - indexed for MEDLINE]
Едем дальше. Интересная статья
J Altern Complement Med. 2006 Jan-Feb;12(1):59-63.
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Abnormally high plasma levels of vitamin B6 in children with autism not taking supplements compared to controls not taking supplements.
Adams JB, George F, Audhya T.
Arizona State University, Tempe, AZ 85287-6006, USA.
jim.adams@asu.edu
BACKGROUND: There have been many studies of the effect of high-dose supplementation of vitamin B6 on children and adults with autism, with all but one reporting benefits. OBJECTIVE: The aim of this study was to investigate the biochemical basis for vitamin B6 therapy by measuring the level of total vitamin B6 in the plasma of unsupplemented children with autism spectrum disorder compared to unsupplemented control subjects. PARTICIPANTS: Children with autism spectrum disorders (n = 35, age 3-9 years) and unrelated typical children (n = 11, age 6-9 years), all from Arizona, were studied. (This includes the data from 24 children with autism from our previous study.) METHODOLOGY: A microbiologic assay was used to measure the level of total vitamin B6 (including phosphorylated and unphosphorylated forms), in a blinded fashion. RESULTS: Children with autism had a 75% higher level of total vitamin B6 than the controls (medians of 56 versus 32 ng/mL, respectively, p = 0.00002). Most of the autistic children (77%) had levels that were more than 2 standard deviations above the median value of the controls. The autistic girls (n = 5) also had elevated levels (mean of 54.6 ng/mL, median of 60 ng/mL). DISCUSSION: These results are consistent with previous studies that found that: (1) pyridoxal kinase had a very low activity in children with autism and (2) pyridoxal 5 phosphate (PLP) levels are unusually low in children with autism. Thus, it appears that the low conversion of pyridoxal and pyridoxine to PLP results in low levels of PLP, which is the active cofactor for 113 known enzymatic reactions, including the formation of many key neurotransmitters. CONCLUSIONS: Total vitamin B6 is abnormally high in autism, consistent with previous reports of an impaired pyridoxal kinase for the conversion of pyridoxine and pyridoxal to PLP. This may explain the many published studies of benefits of high-dose vitamin B6 supplementation in some children and adults with autism.
PMID: 16494569 [PubMed - indexed for MEDLINE]
Получается, что у детей с аутизмом в крови содержание витамина В6 значительно превышает
Да, конечно, имеется много работ, где авторы отмечают положительное влияние высоких доз витамина B6 у взрослых и детей. Но есть ли среди них рандомизированные проспективные работы?
Кто лучше всех умеет сравнивать и суммировать результаты различных исследований?
Кокран, товарищ кокран......